Human Calcium-independent Phospholipase A2 Mediates Lymphocyte Proliferation
نویسندگان
چکیده
منابع مشابه
Human calcium-independent phospholipase A2 mediates lymphocyte proliferation.
Activation of lymphocytes induces blastogenesis and cell division which is accompanied by membrane lipid metabolism such as increased fatty acid turnover. To date little is known about the enzymatic mechanism(s) regulating this process. Release of fatty acids such as arachidonic acid requires sn-2-deacylation catalyzed by a class of enzymes known as phospholipases A(2) (PLA(2), EC ). Herein, we...
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We have investigated the possible involvement of two intracellular phospholipases A(2), namely group VIA calcium-independent phospholipase A(2) (iPLA(2)-VIA) and group IVA cytosolic phospholipase A(2) (cPLA(2)alpha), in the regulation of human promonocytic U937 cell proliferation. Inhibition of iPLA(2)-VIA activity by either pharmacological inhibitors such as bromoenol lactone or methyl arachid...
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PLA2 (phospholipase A2) enzymes play critical roles in membrane phospholipid homoeostasis and in generation of lysophospholipid growth factors. In the present study, we show that the activity of the cytosolic iPLA2 (calcium-independent PLA2), but not that of the calcium-dependent cPLA2 (cytosolic PLA2), is required for growth-factor-independent, autonomous replication of ovarian carcinoma cells...
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Phospholipases A₂ (PLA₂s) represent one of the largest groups of lipid-modifying enzymes. Over the years, significant advances have been made in understanding their potential physiological and pathological functions. Depending on their calcium requirement for activation, PLA₂s are classified into calcium dependent and independent. This paper mainly focuses on brain calcium-independent PLA₂ (iPL...
متن کاملFunction and inhibition of intracellular calcium-independent phospholipase A2.
Our previous Minireview (1) considered the three main kinds of phospholipase A2 (PLA2) : the well characterized Groups I, II, and III small Ca-dependent secretory phospholipase A2s (sPLA2), the 85-kDa Group IV Ca -dependent cytosolic phospholipase A2 (cPLA2), and the 80-kDa Ca -independent cytosolic phospholipase A2 (iPLA2). In the ensuing years, it has become clear that PLA2 represents a growi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m002273200